A new avenue to cure cancer by turning adaptive immune T cells to innate immune NK cells via reprogramming.

نویسندگان

  • Dong-Ming Su
  • Ramakrishna Vankayalapati
چکیده

Thymocytes after T-lineage commitment develop in the T-cell pathway. However, in a recent study, Li et al. (2010) demonstrated that inducing to delete Bcl11b gene in these thymocytes, even in mature T cells turns these cells into natural killer (NK) cells during the culture. They called this conversion 'reprogramming', and the reprogrammed killer cells 'ITNK cells'. The ITNK cells possessed tumor-killer ability and did not indiscriminately kill normal cells. This exciting finding represents a major breakthrough towards curing cancer and identifies an important, novel transcription factor in the thymus development.

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عنوان ژورنال:
  • Journal of molecular cell biology

دوره 2 5  شماره 

صفحات  -

تاریخ انتشار 2010